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RNA-seq PBMCs were thawed in a bead bath at 37 C, topped up with RPMI medium to 10 ml and centrifuged at 300 g for 5 min at room temperature

As awareness of senolytic drugs grows, hospital pharmacies are distinctively positioned to give access to these treatments, mainly for patients dealing with age-related conditions

The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig

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