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Structural impact of chronic cigarette smoking: meta-analytic procedures To identify areas of convergent gray matter decreases across studies, we performed a coordinate-based meta-analysis using the revised version [44, 45] of the activation (in this application, Anatomic) likelihood estimation (ALE) algorithm [26, 46] as implemented in GingerALE v2.3.4 ( ALE is a voxel-wise approach for combining neuroimaging results across a collection of experiments/contrasts and thereby identifying locations of statistically significant spatial convergence

Furthermore, the presence of epicanthal folds and/or infraorbital creases or an association of the other eye findings and/or non-ocular features plus abnormal facial scars seems to denote a further distinctive gestaltic presentation of young cEDS patients, which usually attenuates or even vanishes over the years (Fig

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