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10.1155/2018/7017204 83 Pastor-SolerN

Non-HLA susceptibility genes Beyond the HLA complex, genome-wide association studies have identified more than 60 additional susceptibility loci, several of which play a critical role in the disruption of immune tolerance

It is a regulated cell death pathway characterized by the accumulation of lethal lipid hydroperoxides resulting from tissue iron reacting with esterified polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs such as arachidonic acid [22, 23], while n-3 fatty acids [24], and n-9 monounsaturated fatty acids [25] are protective