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10.1016/j.cbi.2018.07.008 35 HuQ.ZhangW.WuZ.TianX.XiangJ.LiL.et al (2021)

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Biologics for treatment of atopic dermatitis: Current status and future prospect

Furthermore, 5-ASA have some drawbacks as long-term use results in side effects including nausea, vomiting, fatigue, diarrhea, abdominal pain, pulmonary fibrosis, etc (Rogler, 2010)

Additionally, sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA), which pumps calcium from the cytoplasm back into the sarcoplasmic/endoplasmic reticulum, is susceptible to oxidation at cysteine-674, resulting in intracellular calcium overload [93]