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To address the functional role of HSL in vivo, several laboratories generated HSL-null mouse models (44, 94, 134)

North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA

& Wong, G

Imaging 40 , 104114 (2013)

Route of Administration: Intramuscular (IM) injection, typically in the vastus lateralis muscle (thigh)

And this can only happen when there's adequate acid production in the stomach, which as we get older, tends to be a problem since acid levels decrease with age