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doi: 10.1038/nrn3114 68 FaracoGIadecolaC

Additionally, modifiable lifestyle factors, such as diet and exercise, have been shown to influence the tumor microenvironment and may complement anti-angiogenic therapies, potentially improving patient outcomes in colorectal cancer (87)

The accumulation of free cholesterol or phosphatidylcholine may affect sarcoplasmic reticulum/ER Ca 2+ -ATPase (SERCA) activity by changing the free cholesterol (FC)/phospholipid ratio of the ER membrane