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SMAD deletion caused HGF upregulation, contributing to angiogenesis in mice [98]

Cytosolic GR plays crucial roles in: Protecting cellular proteins from oxidative damage and maintaining their proper folding Supporting phase II detoxification pathways that require reduced glutathione as a cofactor Preserving the integrity of cellular membranes by preventing lipid peroxidation Modulating cell signaling pathways sensitive to redox status Defending against xenobiotic compounds that enter the cytoplasm The activity of cytosolic GR is tightly regulated and can be induced under conditions of oxidative stress, providing an adaptive response mechanism to increased free radical production

Expression of CCL19 and CCL21, FRC-produced chemokines that guide dendritic cell migration 9,36 , was also equivalent after infection with wild-type or vCD44BP MCMV (Extended Data Fig

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Furthermore, hemoglobin damaged by ROS may accumulate and form Heinz bodies within erythrocytes [1, 5]