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Cognitive impairment in humanized APPxPS1 mice is linked to Abeta(1-42) and NOX activation

For translation, multi-parameter panels that combine CSF/serum lipid-peroxidation markers (e.g., F 2 -isoprostanes, HNE adducts), protein injury footprints (nitrotyrosine, carbonyls) and compartment-targeted reporters in experimental models (matrix/ER/nuclear H 2 O 2 sensors, peroxiredoxin redox state) and that are aligned to cognitive or motor end-points allow mechanism-anchored evaluation of interventions (Murphy et al

doi: 10.1177/153537020523000906 61 JeongYIJungIDLeeJSLeeCMLeeJDParkYM

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Eur Heart J 43(40):39974126 Ferreira A, Ferreira V, Antunes MM, Lousinha A, Pereira-da-Silva T, Antunes D, Cunha PS, Oliveira M, Ferreira RC, Rosa SA (2023) Dilated cardiomyopathy: a comprehensive approach to diagnosis and risk stratification