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2.8.2 Clinical studies Increased accumulation of iron in substantia nigra of PD patients was observed with MRI techniques in post mortem studies with significant accumulation in putamen, red nucleus, nucleus caudatus and globus pallidus (Wang et al., 2016) and similar imaging findings on nigrosome imaging were found in cases of PD and parkinsonian syndromes ( in vivo assessment of iron dysregulation and supports the thesis that region-specific brain iron accumulation could represent a valuable biomarker in diagnosis, prognosis and disease monitoring in PD and parkinsonism ( Potential association between iron metabolism and T2DM pathobiology has been studied in vivo on a Chinese population of T2DM of middle-aged and elderly patients with evidence of a linear correlation between ferritin levels and risk of developing T2DM (Sun et al., 2013)

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