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Quantitative analysis confirmed that the inhibitory effect of aloe emodin is better than that of emodin, suggesting distinct mechanisms for each compound against breast cancer metastasis [503]

Vitamin D acts as a prohormone

Activation of the farnesoid X receptor (FXR), a ligandactivated nuclear hormone receptor that is a key regulator of bile acid homeostasis, has demonstrated clinical benefit in patients with PSC, as shown by the sustained reduction in serum alkaline phosphatase levels induced by multiple FXR agonists, including obeticholic acid in a phase 2 trial (NCT02177136)

Asparagine bioavailability governs metastasis in a model of breast cancer

[DOI] [PMC free article] [PubMed] [Google Scholar] 150.Yadav AK, Harris-Kawano A, Saxena R, Jiang G, Ji J, Gao H, et al

The pharmacological action of disulfiram (DSF) is attributed to the inhibition of acetaldehyde metabolism by aldehyde dehydrogenase (ALDH) in the liver 2,3