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The recommended daily intake for adults is 2.4 micrograms, but higher doses are also considered safe, as your body absorbs only what it needs, and any excess is passed through urine

Global deletion of monoacylglycerol lipase in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity

[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

Those most at risk of a Vitamin B12 deficiency include elderly people, those who follow a vegetarian or vegan diet, people who have had intestinal surgery and people with diseases of the gut, such as Crohn's Disease or Celiac Disease

doi: 10.1159/000102047

Safe for multi-dose vials