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Since each method typically provides unique information about a specific properties of a protein over different timescales and length scales, the use of such multiparametric approach allows avoiding five blind men and elephant situation (this analogy is based on the ancient parable of the blind men and an elephant, where each person feels a different part of the animal and comes to a completely different conclusion about what an elephant is) (Uversky, 2015a)

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The question therefore was: what exactly do these 15 amino acids do

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