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Management of inflammatory rheumatic conditions in the elderly

This is accompanied by an overwhelming production of pro-inflammatory cytokines in the context of COVID-19, which not only impairs viral clearance but also promotes paradoxical hyperinflammation including CS

Pyruvate + NADH + H + Lactate + NAD + The direction of the reaction depends on lactate dehydrogenase isozymes present and the NADH/NAD + ratio in the cytosol