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SAMe application alleviated these injuries in rats that underwent BDL ( Mat1a in mice resulted in depleted liver SAMe levels and reduced GSH levels, hypermethioninemia, marked changes in the expression of many enzymes of Met metabolism, and increased expression of many acute-phase markers and growth-related genes ( Mat1a - / - mice more susceptible to liver injury (60)

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(3) Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which was reduced by rosiglitazone (Liu et al

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