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Acknowledgements We would like to thank Editage (www.editage.cn/) for providing expert linguistic assistance

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12 13 Again, its benefit in healthy individuals remain unknown

Given the narrow range between inadequate and excessive intake, even minor variations may substantially affect the prevalence of thyroid dysfunction [17]

Mitochondrial abnormalities is ASD patients are consistent with PPA toxicity ETC function testing in muscle demonstrated a partial deficit in complexes I/III and I/III RS activity

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations TMAU, trimethylaminuria