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The insula is notably implicated in gut-related interoceptive processes, as demonstrated by correlations between the sensory reaction of the gastrointestinal tract and increased blood oxygenation level dependent (BOLD) signals in the insula ( The negative correlation between GSRS scores and Asp and NAAG and similar trend observed in Ins, can be interpreted as follows: Aspartate functions as an excitatory neurotransmitter that engages the N -methyl-D-aspartate receptor (NMDAR), which is implicated in the modulation of visceral pain hypersensitivity and, consequently, in central sensitization to pain (Willert et al., 2004)

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