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Overall, these results confirmed the consistency of these antibodies used in the study and reinforce the conclusion that ferroptosis is the mode of cell death triggered in the lungs of patients with fatal COVID-19 disease

In situ immunofluorescence of NRF2 also indicated this protein is highly expressed and present in the nucleus of A549 cells, with lesser expression in the nucleus of H23 cells (representative results shown in Supplementary Fig

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In conclusion, TNBC is an aggressive and heterogeneous tumor that requires more selective treatment, and the xCT/NRF2/ OSGIN1 axis is a novel specific target for the treatment of MSL/CL subtypes overexpressing SLC7A11 , which may be more effective than GSH depletion

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