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doi: 10.1177/1933719117702247 48 LewisEDRichardCGorukSDellschaftNSCurtisJMJacobsRLet al

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133 4-HNE readily forms covalent adducts with nucleophilic amino acid residuesparticularly cysteine, histidine, and lysinethrough Michael addition or Schiff base formation, frequently resulting in protein misfolding, unfolding, or aggregation