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In PCOS, oxidative stress contributes to: Hormonal disruption Insulin resistance Inflammation Poor skin recovery Pigmentation flare-ups Glutathione helps by: Reducing free radical damage Supporting cellular repair Calming stress-driven melanin activity This is why skin issues in PCOS often improve after internal balance improves , not before

The relative importance of those physiological processes and their interactions depend upon the prevailing activities, as illustrated in Table 4 below ( Armstrong 2007 )

Further investigation using immunofluorescence and western blotting demonstrated that SIRT1 levels were near baseline at 4 h post-exposure, declined markedly by 24 h, and persisted at reduced levels until day 7 (Fig