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Name: glutathione synthetase requires REGULATION OF SYNTHESIS Glutathione Synthetase Deficiency as a
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Neurosci Biobehav Rev (2013) 37(10):255463

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Gu et al., 2003) have shown that the activation of M1-mAChR promotes the -secretase-mediated cleavage of APP, thereby inhibiting its cleavage by BACE-1 and -secretase to produce neurotoxic A, and can significantly reduce A excitatory neurotoxicity (action potential firing and excitatory postsynaptic currents)