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isolating the acetyl-L-carnitine nitrate comprises: distilling the reaction of acetyl-L-carnitine free base and nitric acid to remove the other products of the reaction

As Mcl-2 has a shorter half-life than neutrophils (around 23 h) and neutrophils do not express other bcl-2 family proteins, vigorous protein synthesis is required for neutrophil survival, and impaired protein and amino acid metabolism can lead to apoptosis ( Figure 2 )

Bocckino et al., 1991

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