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A 2023 review identified other medications with little or mixed evidence, including (Yeh 2023): Clonidine (Catapres), a drug that acts in the central nervous system to reduce sympathetic outflow, ultimately leading to effects such as decreased vascular resistance, reduced heart rate, and lower blood pressure Perampanel (Fycompa), amantadine (Gocovri), ketamine (Ketalar), and cannabinoids, which directly inhibit glutamate signaling Lamotrigine (Lamictal), topiramate (Topamax), oxcarbazepine (Trileptal), and levetiracetam (Keppra), which like gabapentinoids, are antiseizure drugs More research is needed to determine whether any of these medications can be considered as reasonable options in RLS treatment

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Maestri, A., De Pasquale, Ceratti A., Cundari, S., Zanna, C., Cortesi, E., and Crino, L

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In addition to providing energy, ketones have neuroprotective properties, helping to prevent cognitive decline during prolonged periods of caloric deprivation