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10.1023/A:1015554616358 91 PengH.-Y.YangX.-E.YangM.-J.TianS.-K

1 Introduction Rheumatoid arthritis (RA) is a multifactorial chronic autoimmune disease of unknown aetiology, which typically involves the joints and mostly manifests as symmetric polyarthritis in the large and small joints ( As a fundamental organelle, mitochondria are known as the energy centre of cells, which execute and coordinate various metabolic processes within cells and meet the energy demands of cells through the oxidative phosphorylation (OXPHOS) system

However, a recently published phase II clinical trial using the iron chelator deferiprone reported that deferiprone was ineffective in newly diagnosed PD patients who had not previously received dopaminergic therapy and even worsened both motor and non-motor symptoms [177]

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Redner A, Hegewisch-Becker S, Smith M, Squires J, Andreeff M